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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salgado, Edinson | RP | Free Agent | 21 | 01/06/2005 | Corozal | COL | Left | Left | 6' 0" | 150 lbs | - |
| Salina, Michael | SP | San Diego (ACL) Padres | 22 | 01/30/2004 | Rochester | USA | Right | Right | 6' 1" | 215 lbs | - |
| Sanchez, Adolfo | RF | Cincinnati (ACL) Reds | 19 | 09/19/2006 | Santo Domingo | DOM | Left | Left | 6' 2" | 175 lbs | - |
| Sanchez, Javier | C | Texas (ACL) Rangers | 18 | 08/17/2007 | Barquisimeto | VEN | Right | Right | 5' 11" | 160 lbs | - |
| Sanchez, Julius | SP | Texas (ACL) Rangers | 22 | 10/19/2003 | LaSalle | USA | Right | Right | 6' 0" | 210 lbs | - |
| Sanchez, Junior | SP | Arizona (ACL) Diamondbacks | 20 | 09/16/2005 | Santo Domingo | DOM | Right | Right | 5' 10" | 175 lbs | - |
| Sanchez, Yohendry | C | San Francisco (ACL) Giants | 19 | 11/09/2006 | Valencia | VEN | Right | Right | 5' 11" | 200 lbs | - |
| Santana, Sandro | RP | Arizona (ACL) Diamondbacks | 21 | 03/07/2005 | Barahona | DOM | Left | Left | 5' 10" | 150 lbs | - |
| Sarver, Joel | RP | Arizona (ACL) Diamondbacks | 24 | 12/04/2001 | Champaign | USA | Right | Right | 6' 1" | 190 lbs | - |
| Savary, Aaron | RP | Cleveland (ACL) Guardians | 21 | 07/21/2004 | Dubuque | USA | Right | Right | 6' 3" | 180 lbs | - |
| Scheffler, Dominic | RP | Cincinnati (ACL) Reds | 21 | 07/27/2004 | Zurich | SUI | Left | Left | 6' 4" | 195 lbs | - |
| Schiefer, Ryan | RP | Chicago A (ACL) White Sox | 22 | 08/19/2003 | Gilbert | USA | Right | Right | 6' 3" | 170 lbs | - |
| Schmitt, Tyler | RP | San Diego (ACL) Padres | 21 | 08/10/2004 | Madison | USA | Right | Right | 6' 3" | 200 lbs | - |
| Schoenwetter, Cole | RP | Cincinnati (ACL) Reds | 21 | 10/01/2004 | Santa Barbara | USA | Right | Right | 6' 3" | 190 lbs | - |
| Seeley, Trey | RP | San Francisco (ACL) Giants | 23 | 06/28/2002 | Fountain Valley | USA | Right | Right | 6' 2" | 195 lbs | - |
| Sentlinger, Andrew | RP | Chicago A (ACL) White Sox | 22 | 10/13/2003 | Summit | USA | Left | Left | 6' 2" | 200 lbs | - |
| Shaffner, Andrew | RP | Cincinnati (ACL) Reds | 23 | 12/31/2002 | Galax | USA | Left | Right | 6' 2" | 185 lbs | - |
| Sheehan, Tommy | RP | Chicago A (ACL) White Sox | 26 | 06/17/1999 | Brielle | USA | Left | Left | 6' 0" | 210 lbs | - |
| Shelton, Easton | 1B | Los Angeles N (ACL) Dodgers | 20 | 09/17/2005 | Las Vegas | USA | Right | Right | 6' 5" | 225 lbs | - |
| Shepardson, Blake | RP | Chicago A (ACL) White Sox | 22 | 07/06/2003 | Highlands Ranch | USA | Right | Right | 6' 5" | 220 lbs | - |
| Shores, Chase | SP | Los Angeles A (ACL) Angels | 21 | 05/21/2004 | Midland | USA | Right | Right | 6' 8" | 245 lbs | - |
| Siguenza, Kason | 3B | Los Angeles A (ACL) Angels | 18 | 10/12/2007 | Abbotsford | CAN | Left | Right | 5' 10" | 170 lbs | - |
| Silva, Heribert | CF | Cleveland (ACL) Guardians | 19 | 03/31/2006 | Barquisimeto | VEN | Left | Left | 5' 9" | 150 lbs | - |
| Silva, Jose | 2B | Chicago N (ACL) Cubs | 18 | 04/26/2007 | Valdosta | USA | Right | Right | 5' 10" | 180 lbs | - |
| Sinzza, Kyle | 2B | Arizona (ACL) Diamondbacks | 18 | 04/11/2007 | Caracas | VEN | Right | Right | 5' 9" | 160 lbs | - |
| Slawinski, Johnny | SP | Los Angeles A (ACL) Angels | 19 | 02/26/2007 | San Antonio | USA | Left | Left | 6' 3" | 180 lbs | - |
| Smith, Brady | RP | Los Angeles N (ACL) Dodgers | 21 | 01/27/2005 | Bean Station | USA | Right | Right | 6' 2" | 170 lbs | - |
| Smith, Darien | RP | San Francisco (ACL) Giants | 26 | 11/30/1999 | Jacksonville | USA | Right | Right | 6' 3" | 205 lbs | - |
| Smith, Derrick | RP | Colorado (ACL) Rockies | 22 | 12/01/2003 | White Bear Lake | USA | Right | Right | 6' 2" | 220 lbs | - |
| Smith, Russell | RP | Milwaukee (ACL) Brewers | 27 | 09/10/1998 | Midlothian | USA | Left | Left | 6' 7" | 255 lbs | - |
| Snead, Nate | SP | Los Angeles A (ACL) Angels | 22 | 03/16/2004 | South Milwaukee | USA | Right | Right | 6' 2" | 210 lbs | - |
| Soriano, Yeycol | LF | Cincinnati (ACL) Reds | 20 | 09/03/2005 | San Pedro de Macorís | DOM | Left | Left | 6' 0" | 150 lbs | - |
| Sosa, Ivan | 2B | Free Agent | 21 | 09/09/2004 | Santo Domingo | DOM | Right | Right | 5' 11" | 180 lbs | - |
| Soto, Ubaldo | RP | Los Angeles A (ACL) Angels | 19 | 07/12/2006 | Sabana Larga | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Steensma, Jackson | SP | Seattle (ACL) Mariners | 22 | 03/12/2004 | Grand Rapids | USA | Switch | Right | 6' 4" | 245 lbs | - |
| Sullivan, Cameron | SP | Cleveland (ACL) Guardians | 19 | 03/22/2006 | Indianapolis | USA | Right | Right | 6' 2" | 200 lbs | - |
