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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sacco Jr., Tommy | SS | Fayetteville Woodpeckers | 26 | 05/21/1999 | Chandler | USA | Switch | Right | 5' 10" | 195 lbs | - |
| Salazar, Kleyver | C | Salem RidgeYaks | 19 | 05/01/2006 | Barcelona | VEN | Right | Right | 6' 1" | 185 lbs | - |
| Sales, R.J. | SP | Fredericksburg Nationals | 22 | 07/22/2003 | Pinehurst | USA | Right | Right | 6' 0" | 165 lbs | - |
| Sanchez, Camilo | CL | Fredericksburg Nationals | 22 | 06/28/2003 | Panama | PAN | Right | Right | 6' 2" | 165 lbs | - |
| Sanchez, Jordan | CF | Delmarva Shorebirds | 20 | 10/09/2005 | Matanzas | CUB | Left | Left | 6' 1" | 175 lbs | - |
| Sanchez, Juan | RP | Augusta GreenJackets | 22 | 05/21/2003 | Hato Mayor | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Sanders, Josh | RP | Hickory Crawdads | 24 | 10/22/2001 | Yukon | USA | Right | Right | 6' 3" | 165 lbs | - |
| Santana, Paulino | LF | Hickory Crawdads | 19 | 11/17/2006 | Santo Domingo | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Saucke, Casey | RF | Kannapolis Cannon Ballers | 22 | 07/24/2003 | Rochester | USA | Right | Right | 6' 3" | 210 lbs | - |
| Savage, Luke | RP | Hickory Crawdads | 24 | 08/10/2001 | Dallas | USA | Right | Right | 6' 1" | 200 lbs | - |
| Schanaman, Shay | RP | Augusta GreenJackets | 26 | 08/12/1999 | Grand Island | USA | Right | Right | 6' 0" | 205 lbs | - |
| Schubart, Nolan | 1B | Hill City Howlers | 21 | 05/10/2004 | Durand | USA | Left | Right | 6' 5" | 225 lbs | - |
| Schuelke, Cam | RP | Hill City Howlers | 24 | 01/14/2002 | Dorr Township | USA | Right | Right | 6' 0" | 185 lbs | - |
| Schultz, Thomas | RP | Fredericksburg Nationals | 26 | 08/03/1999 | Mt. Carmel | USA | Right | Right | 6' 6" | 245 lbs | - |
| Segura, Enrique | SP | Hickory Crawdads | 21 | 12/19/2004 | San Pedro de Macorís | DOM | Right | Right | 6' 3" | 175 lbs | - |
| Seijas, Kegnnalex | C | Wilson Warbirds | 20 | 11/05/2005 | San Felipe | VEN | Right | Right | 5' 8" | 150 lbs | - |
| Shafer, Jacob | SP | Augusta GreenJackets | 23 | 04/30/2002 | High Point | USA | Right | Right | 6' 8" | 240 lbs | - |
| Shaffer, Bryce | SP | Charleston RiverDogs | 24 | 08/03/2001 | Fairfax | USA | Left | Left | 5' 2" | 185 lbs | - |
| Shelton, Colby | SS | Kannapolis Cannon Ballers | 23 | 12/06/2002 | Lithia | USA | Left | Right | 6' 0" | 205 lbs | - |
| Shields, David | SP | Columbia Fireflies | 19 | 09/09/2006 | Pittsburgh | USA | Switch | Left | 6' 2" | 210 lbs | - |
| Siary, Evan | SP | Hickory Crawdads | 22 | 10/18/2003 | Inman | USA | Right | Right | 6' 1" | 205 lbs | - |
| Sierra, Joel | RP | Free Agent | 24 | 12/31/2001 | Santo Domingo | DOM | Right | Right | 6' 1" | 190 lbs | - |
| Silva, Anthony | 2B | Hill City Howlers | 22 | 07/17/2003 | San Antonio | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sinibaldi, Justin | SP | Kannapolis Cannon Ballers | 24 | 03/03/2002 | Bridgewater Township | USA | Left | Left | 6' 4" | 215 lbs | - |
| Smith, Brayden | RF | Delmarva Shorebirds | 22 | 12/15/2003 | Las Vegas | USA | Left | Right | 6' 0" | 190 lbs | - |
| Smith, Parker | SP | Fayetteville Woodpeckers | 23 | 03/05/2003 | Bellaire | USA | Right | Right | 6' 4" | 230 lbs | - |
| Southisene, Tate | SS | Augusta GreenJackets | 19 | 10/06/2006 | Henderson | USA | Right | Right | 5' 11" | 180 lbs | - |
| Southisene, Ty | 2B | Myrtle Beach Pelicans | 20 | 07/08/2005 | Henderson | USA | Right | Right | 5' 9" | 160 lbs | - |
| Spears, Brayden | RP | Myrtle Beach Pelicans | 25 | 02/27/2001 | Brentwood | USA | Right | Right | 6' 6" | 225 lbs | - |
| Springer, Josh | C | Hickory Crawdads | 19 | 06/12/2006 | Corona | USA | Right | Right | 6' 3" | 205 lbs | - |
| Stark, Cal | C | Hickory Crawdads | 23 | 07/27/2002 | Knoxville | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sullivan, Liam | SP | Fredericksburg Nationals | 23 | 05/16/2002 | Sandy Springs | USA | Left | Left | 6' 6" | 250 lbs | - |
| Summerhill, Brendan | CF | Charleston RiverDogs | 22 | 11/13/2003 | Chicago | USA | Left | Right | 6' 3" | 205 lbs | - |
| Susac, Anthony | RP | Hickory Crawdads | 23 | 07/31/2002 | Sacramento | USA | Right | Right | 6' 3" | 215 lbs | - |
