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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sailors, Nolan | LF | Quad Cities River Bandits | 22 | 07/04/2003 | Omaha | USA | Left | Right | 6' 0" | 190 lbs | - |
| Saladin, Darlin | RP | Peoria Chiefs | 23 | 12/28/2002 | San Pedro de Macorís | DOM | Right | Right | 5' 11" | 150 lbs | - |
| Salas, Gerardo | SP | Free Agent | 23 | 02/14/2003 | Monterrey | MEX | Right | Right | 6' 0" | 190 lbs | - |
| Salazar, Braian | SP | Fort Wayne TinCaps | 20 | 06/12/2005 | Barcelona | VEN | Left | Left | 6' 2" | 165 lbs | - |
| Sanchez, Franklin | RP | Beloit Sky Carp | 25 | 09/12/2000 | Jimaní | DOM | Right | Right | 6' 6" | 185 lbs | - |
| Santana, Cristian | 3B | West Michigan Whitecaps | 22 | 11/25/2003 | Azua | DOM | Right | Right | 5' 11" | 165 lbs | - |
| Santana, Tyler | RP | South Bend Cubs | 27 | 05/13/1998 | Miami Springs | USA | Right | Right | 6' 1" | 205 lbs | - |
| Santos, Nolan | RP | Cedar Rapids Kernels | 25 | 12/07/2000 | Miami Beach | USA | Right | Right | 6' 1" | 205 lbs | - |
| Santy, Marino | SP | South Bend Cubs | 24 | 03/04/2002 | Santo Domingo | DOM | Left | Left | 5' 11" | 170 lbs | - |
| Savacool, Jason | SP | Peoria Chiefs | 23 | 05/21/2002 | Baldwinsville | USA | Right | Right | 6' 1" | 210 lbs | - |
| Schultz, Connor | RP | South Bend Cubs | 27 | 02/12/1999 | Cedar Falls | USA | Right | Right | 6' 4" | 225 lbs | - |
| Scott, Kyle | RP | Lake County Captains | 23 | 04/16/2002 | Westminster | USA | Right | Right | 6' 1" | 220 lbs | - |
| Seppings, Jack | RP | Wisconsin Timber Rattlers | 23 | 07/03/2002 | Newnan | USA | Right | Right | 6' 1" | 190 lbs | - |
| Serwa, Kenny | RP | West Michigan Whitecaps | 28 | 08/03/1997 | Chicago | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sha, Tzu-Chen | SP | Lansing Lugnuts | 22 | 10/15/2003 | Taipei | TPE | Right | Right | 6' 2" | 195 lbs | - |
| Shaw, Evan | RP | Great Lakes Loons | 25 | 02/02/2001 | Fridley | USA | Left | Left | 6' 4" | 205 lbs | - |
| Showalter, Zack | RP | Peoria Chiefs | 22 | 01/23/2004 | Wesley Chapel | USA | Right | Right | 6' 2" | 195 lbs | - |
| Shunck, RJ | RP | Beloit Sky Carp | 22 | 12/31/2003 | Swanton | USA | Right | Left | 6' 7" | 190 lbs | - |
| Silva, Gabriel | C | Quad Cities River Bandits | 22 | 12/10/2003 | Ciudad Bolívar | VEN | Right | Right | 5' 10" | 195 lbs | - |
| Simmons, Dylan | RP | Dayton Dragons | 25 | 10/05/2000 | Jacksonville | USA | Right | Right | 6' 3" | 225 lbs | - |
| Simon, Johan | RP | West Michigan Whitecaps | 24 | 07/01/2001 | La Romana | DOM | Left | Left | 6' 1" | 165 lbs | - |
| Sloan, Ethan | CL | West Michigan Whitecaps | 23 | 08/04/2002 | Denver | USA | Left | Left | 5' 11" | 190 lbs | - |
| Smeltz, Jackson | RP | Fort Wayne TinCaps | 27 | 09/14/1998 | Lafayette | USA | Left | Left | 6' 3" | 210 lbs | - |
| Smith, Jake | RP | Beloit Sky Carp | 26 | 10/04/1999 | Chapel Hill | USA | Right | Right | 6' 4" | 190 lbs | - |
| Smith, Travis | SP | Wisconsin Timber Rattlers | 23 | 11/09/2002 | Walton | USA | Right | Right | 6' 4" | 220 lbs | - |
| Snell, Kade | LF | South Bend Cubs | 23 | 07/29/2002 | Dothan | USA | Left | Left | 6' 1" | 225 lbs | - |
| Soto, Charlee | SP | Cedar Rapids Kernels | 20 | 08/31/2005 | Kissimmee | USA | Switch | Right | 6' 5" | 210 lbs | - |
| Spencer, Connor | RP | South Bend Cubs | 25 | 11/04/2000 | Hernando | USA | Left | Right | 6' 2" | 215 lbs | - |
| Stanley, Hunter | RP | Lake County Captains | 28 | 11/25/1997 | Hammond | USA | Right | Right | 6' 0" | 190 lbs | - |
| Starks, Gabe | RP | Dayton Dragons | 24 | 12/26/2001 | Pine Bluff | USA | Right | Right | 6' 1" | 230 lbs | - |
| Stephan, Anthony | CF | Dayton Dragons | 23 | 12/16/2002 | Ridgewood | USA | Left | Right | 5' 11" | 195 lbs | - |
| Stone, Adam | RP | South Bend Cubs | 24 | 07/31/2001 | Stamford | USA | Right | Right | 6' 6" | 210 lbs | - |
| Stovall, Peyton | 2B | Dayton Dragons | 23 | 02/14/2003 | Haughton | USA | Left | Right | 6' 0" | 185 lbs | - |
| Stransky, Justin | C | South Bend Cubs | 23 | 09/10/2002 | Renton | USA | Right | Right | 6' 1" | 180 lbs | - |
| Stull, Eston | RP | Cedar Rapids Kernels | 27 | 01/20/1999 | Pendleton | USA | Right | Right | 6' 2" | 205 lbs | - |
| Suarez, Jose | RF | Peoria Chiefs | 21 | 08/09/2004 | Baní | DOM | Right | Right | 6' 3" | 200 lbs | - |
