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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salas, Hector | 1B | Asheville Tourists | 22 | 03/19/2004 | Higüey | DOM | Left | Right | 5' 11" | 145 lbs | - |
| Salazar, Grabiel | RP | Frederick Keys | 25 | 02/19/2001 | Punta de Piedras | VEN | Right | Right | 6' 0" | 165 lbs | - |
| Saltiban, Devin | 2B | Jersey Shore BlueClaws | 21 | 02/14/2005 | Hilo | USA | Right | Right | 5' 9" | 175 lbs | - |
| Samuels, Logan | RP | Rome Emperors | 24 | 02/18/2002 | Jasper | USA | Right | Right | 6' 4" | 170 lbs | - |
| Sanchez, Luis | 2B | Rome Emperors | 22 | 01/16/2004 | Panama | PAN | Right | Right | 5' 9" | 165 lbs | - |
| Sanchez, Luis | RP | Frederick Keys | 23 | 03/04/2003 | San Francisco de Macorís | DOM | Right | Right | 6' 0" | 170 lbs | - |
| Sanchez, Wilmy | RP | Asheville Tourists | 22 | 12/17/2003 | Santiago | DOM | Right | Right | 5' 9" | 210 lbs | - |
| Santa Maria, Tony | 3B | Bowling Green Hot Rods | 23 | 04/06/2002 | Absecon | USA | Right | Right | 5' 11" | 200 lbs | - |
| Santana, Adrian | SS | Bowling Green Hot Rods | 20 | 07/18/2005 | Miami | USA | Switch | Right | 5' 11" | 160 lbs | - |
| Santos, Yeriel | RP | Asheville Tourists | 22 | 11/20/2003 | San Francisco de Macorís | DOM | Right | Right | 6' 0" | 165 lbs | - |
| Scarborough, Caden | SP | Hub City Spartanburgers | 20 | 04/01/2005 | St. Cloud | USA | Right | Right | 6' 5" | 185 lbs | - |
| Scott, Quincy | LF | Hub City Spartanburgers | 23 | 01/15/2003 | San Marcos | USA | Right | Right | 6' 5" | 220 lbs | - |
| Sellers, Trent | RP | Hudson Valley Renegades | 26 | 10/30/1999 | Kennewick | USA | Right | Right | 6' 1" | 205 lbs | - |
| Seminaris, Adam | RP | Jersey Shore BlueClaws | 27 | 10/19/1998 | Chino Hills | USA | Right | Left | 6' 0" | 190 lbs | - |
| Serna, Luis | RP | Hudson Valley Renegades | 21 | 07/20/2004 | San Luis Río Colorado | MEX | Right | Right | 5' 11" | 145 lbs | - |
| Serrano, Jose | RP | Asheville Tourists | 22 | 02/14/2004 | Bonao | DOM | Right | Right | 6' 2" | 210 lbs | - |
| Sharkey, Teddy | RP | Free Agent | 24 | 08/01/2001 | Wall Township | USA | Right | Right | 6' 0" | 195 lbs | - |
| Shirk, Jake | SP | Greensboro Grasshoppers | 23 | 06/05/2002 | Fort Wayne | USA | Right | Right | 6' 2" | 200 lbs | - |
| Shojinaga, Kodey | C | Jersey Shore BlueClaws | 23 | 02/22/2003 | Honolulu | USA | Right | Right | 5' 10" | 190 lbs | - |
| Simon, Ben | RP | Brooklyn Cyclones | 23 | 03/22/2002 | Hightstown | USA | Left | Right | 5' 11" | 195 lbs | - |
| Simpson, Jared | RP | Wilmington Blue Rocks | 25 | 06/28/2000 | Clinton | USA | Left | Left | 6' 4" | 205 lbs | - |
| Sinnard, Luke | SP | Rome Emperors | 23 | 10/21/2002 | Hendersonville | USA | Right | Right | 6' 8" | 250 lbs | - |
| Smith, Boston | C | Wilmington Blue Rocks | 23 | 11/28/2002 | Vandalia | USA | Left | Right | 5' 10" | 195 lbs | - |
| Smith, Tanner | CL | Frederick Keys | 23 | 08/05/2002 | Duxbury | USA | Right | Right | 6' 6" | 245 lbs | - |
| Smith, Tanner | C | Rome Emperors | 23 | 09/26/2002 | Chandler | USA | Right | Right | 6' 0" | 200 lbs | - |
| Snelsire, Hayden | RP | Bowling Green Hot Rods | 25 | 01/16/2001 | Berlin | USA | Right | Right | 6' 3" | 205 lbs | - |
| Spikerman, John | CF | Jersey Shore BlueClaws | 22 | 04/02/2003 | Montgomery | USA | Switch | Right | 6' 0" | 180 lbs | - |
| Spikes, Ryan | 2B | Bowling Green Hot Rods | 23 | 03/13/2003 | Covington | USA | Right | Right | 5' 9" | 180 lbs | - |
| Sprague, Shea | SP | Greenville Drive | 23 | 01/03/2003 | Hanover | USA | Right | Left | 6' 3" | 195 lbs | - |
| Stafford, Ryan | RF | Frederick Keys | 23 | 01/15/2003 | Folsom | USA | Right | Right | 5' 10" | 180 lbs | - |
| Stafura, Sammy | SS | Greensboro Grasshoppers | 21 | 11/15/2004 | Mohegan Lake | USA | Right | Right | 6' 0" | 185 lbs | - |
| Stasio, Cole | RP | Hub City Spartanburgers | 24 | 09/10/2001 | Davie | USA | Right | Right | 6' 4" | 210 lbs | - |
| Stebens, Isaac | SP | Greenville Drive | 24 | 12/05/2001 | Stillwater | USA | Right | Right | 6' 0" | 195 lbs | - |
| Steels, Jake | CF | Rome Emperors | 23 | 06/17/2002 | Santa Maria | USA | Right | Right | 6' 0" | 185 lbs | - |
| Stevens, Kevin | RP | Hudson Valley Renegades | 28 | 01/26/1998 | Tucson | USA | Right | Right | 6' 2" | 225 lbs | - |
| Steward, Casey | SP | Jersey Shore BlueClaws | 24 | 08/02/2001 | Wichita | USA | Right | Right | 6' 5" | 260 lbs | - |
| Sthele, Travis | SP | Wilmington Blue Rocks | 24 | 09/21/2001 | San Antonio | USA | Right | Right | 6' 0" | 200 lbs | - |
| Strickland, Samuel | RP | Rome Emperors | 26 | 03/26/1999 | Birmingham | USA | Right | Left | 6' 2" | 220 lbs | - |
| Stumbo, Peyton | RP | Greensboro Grasshoppers | 24 | 01/05/2002 | Auburn | USA | Right | Right | 6' 1" | 200 lbs | - |
| Suero, Estuar | LF | Greensboro Grasshoppers | 20 | 08/29/2005 | San Pedro de Macorís | DOM | Switch | Right | 6' 5" | 180 lbs | - |
| Sulbaran, Juan | C | Hub City Spartanburgers | 20 | 10/01/2005 | Mérida | VEN | Right | Right | 5' 11" | 165 lbs | - |
| Swanson, Nic | RP | Asheville Tourists | 26 | 07/08/1999 | Bixby | USA | Right | Right | 6' 2" | 180 lbs | - |
